New TRR paper! Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites
An improved synthesis for tryptophan-dehydrobutyrine diketopiperazine (TDD), a co-metabolite of the hybrid polyketide/non-ribosomal peptide hangtaimycin, starting from ʟ-tryptophan is presented. Comparison…More
New paper! Native metabolomics identifies the rivulariapeptolide family of protease inhibitors
The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is…More
New TRR-paper! Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporterThe transport of substances across the membrane into the cell is performed by specific membrane transport proteins. Scientists at the University Hospital Bonn (UKB) and the University… More
Dr. Axel Walter has just received the Teufel-Foundation-Award!
It is our great pleasure to announce that Dr. Axel Walter has just received the Teufel-Foundation-Award for excellent scientific results and his PhD-thesis! Congratulations to Axel Walter and to Prof.…More
Andreas Peschel erhält Emil von Behring-Preis
Philipps-Universität Marburg awards the Emil von Behring Prize 2021 to Prof. Dr. Andreas Peschel. He is honored for his outstanding research in the field of pathophysiology of pathogens. The award ceremony…More
New TRR-paper! Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes
Congratulations to Athina Gavriilidou, Satria Kautsar, Nestor Zaburannyi, Daniel Krug, Rolf Müller, Marnix Medema and Nadine Ziemert!
By analyzing a huge number of bacterial genomes for potentially…More
New TRR-publication! Versatile synthesis of pathogen specific bacterial cell wall building blocks
Congratulations to Lukas Martin Wingen, Christina Braun, Marvin Rausch, Harald Gross, Tanja Schneider and Dirk Menche!
A modular three coupling strategy involving a versatile solid phase peptide…More
New TRR-paper! Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis.The catalytic cycle of ClpP is dynamic and ADEP helped to shed further light on the details and intermittent stages: Delineating the mechanisms of substrate engagement and product release … More
New TRR-paper! A data management infrastructure for the integration of imaging and omics data in life sciences
Authors describe a data management architecture for integrated, FAIR-supporting management of omics and biomedical imaging data, and exemplify its applicability for basic biology research and clinical…More
New TRR publication! Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules
In a collaborative effort, several of our TRR members unraveled the multi-layered mode of action of a new clotrimazole-linked carbon-monoxide releasing antibacterial agent. Congratulations to all authors!