New TRR261-publication! The hypersusceptible antibiotic screening strain Staphylococcus aureus SG511-Berlin harbors multiple mutations in regulatory genes
The genetic plasticity of Staphylococcus aureus has facilitated the evolution of many virulent and drug-resistant strains. Here we present the sequence of the 2.74 Mbp genome of S. aureus SG511-Berlin,…More
TRR261 GOES BLUE!
TRR261 goes blue :
• To make AMR a globally recognized issue with engagement of all sectors - human, animal, plant and environment, a 'One Health approach'.More
• To raise awareness of the need…
Spitzenforschung trifft Politik!
Gelungener Austausch mit Annette Widmann-Mauz zur Forschung im Bereich Mikrobiologie/Infektionsforschung Tübinger und überregionaler Forschungsverbünde…More
New paper! THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates
Considering the alarming emergence of resistance to most antibiotics and the need for new antibiotics, the finding here of a small-molecule class, THCz, that displayed bactericidal activity…More
World Antimicrobial Awareness Week 2021
Antibiotics are the heart of health
Antibiotics have revolutionised medicine and saved millions of lives in the past 8 decades.…More
"Den körpereigenen Schutzschild aktivieren" — Prof. H. Brötz-Oesterhelt was a guest of the regional newspaper
Our TRR261-CellMAP Spokesperson, Prof. Heike Brötz-Oesterhelt, was a guest of the week in the Newspaper Schwäbisches Tagblatt .
The interview concerned following topics: how we deal…More
New paper! Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated…More
New publication! Contribution of the Clp Protease to Bacterial Survival and Mitochondrial Homoeostasis.
Fast adaptation to environmental changes ensures bacterial survival, and proteolysis represents a key cellular process in adaptation. The Clp protease system is a multi-component machinery responsible…More
New paper! Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides…More