• World Antimicrobial Awareness Week 2022

    Gemeinsam gegen Antibiotika-Resistenzen

    Antibiotika sind bis heute unsere wichtigste Waffe gegen bakterielle Infektionen. Jedoch verlieren sie zunehmend an Wirkung, da Antibiotikaresistenzen…

  • New TRR-publication! The Substrate Scope of Dehydratases in Antibiotic Biosynthesis and their Application in Kinetic Resolutions

    Congratulations to Zhiyong Yin,  Daniel Baer, Bertolt Gust and Jeroen Dickschat on their recent publication!
  • New TRR-publication! Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis

    Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different…

  • Annika Krüger receives Sigrid Peyerimhoff-Award

    It is our great pleasure to announce that Annika Krüger received the Sigrid Peyerimhoff-Preis 2022! As a MSc-student from the University of Bonn (Prof. Dr. Kubitscheck’s research group) she received…

  • New TRR paper! Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane

    Actinobacteria have traditionally been an important source of bioactive natural products, although many genera remain poorly explored. Here, we report a group of distinctive pyrrole-containing natural…

  • New TRR publication! Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes

    Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of  More
  • Unsere TRR261-Sprecherin, Prof. H. Brötz-Oesterhelt, ist als Expertin in "I am a Scientist" dabei!


    Bei I’m a Scientist drehte sich in dieser Themenrunde alles um den „Infektionen”. Schüler*innen haben die Möglichkeit, vielen spannenden Fragen rund um das Thema nachzugehen:

  • New TRR paper! Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

    An improved synthesis for tryptophan-dehydrobutyrine diketopiperazine (TDD), a co-metabolite of the hybrid polyketide/non-ribosomal peptide hangtaimycin, starting from ʟ-tryptophan is presented. Comparison…

  • New paper! Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

    The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is…

  • New TRR-paper! Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter

    The transport of substances across the membrane into the cell is performed by specific membrane transport proteins. Scientists at the University Hospital Bonn (UKB) and the University…