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Bianchi M., Winterhalter M, Harbig TA, Hörömpöli D, Ghai I, Nieselt K, Brötz-Oesterhelt H, Mayer Ch, Borisova-Mayer MFosfomycin uptake in Escherichia coli is mediated by the outer-membrane porins OmpF, OmpC, and LamB. ACS Infect. Dis. (2023) doi: 10.1021/acsinfecdis.3c00367

Brajtenbach D, Puls JS, Matos de Opitz CL, Sass PKubitscheck UGrein F. Quantitative analysis of microscopy data to evaluate bacterial responses to antibiotic treatment. In Peter Sass (ed.), Antibiotics: Methods and Protocols, Methods in Molecular Biology 2nd edition, vol. 2601. Springer, New York. (2023).

Braun  C, Wingen L, Menche D. Strategies and tactics for synthesis of Lipid I and II and shortened analogs: functional building blocks of bacterial cell wall biosynthesis, Nat. Prod. Rep. (2023). 

Goldfinger V, Spohn M, Rodler J, Sigle M, Kulik A, Cryle MJ, Rapp J, Link H, Wohlleben W, Stegmann E. Metabolic engineering of the shikimate pathway in Amycolatopsis strains for optimized glycopeptide antibiotic production. Metab. Engineer. (2023).

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Matos de Opitz CL, Sass P. Microscopy-based multiwell assay to characterize disturbed bacterial morphogenesis upon antibiotic action. In Peter Sass (ed.), Antibiotics: Methods and Protocols, Methods in Molecular Biology 2nd edition, vol. 2601. Springer, New York. (2023).

Middelhauve V, Kubitscheck U. Expansion Microscopy of Bacillus subtilis. In Peter Sass (ed.), Antibiotics: Methods and Protocols, Methods in Molecular Biology 2nd edition, vol. 2601. Springer, New York. (2023).

Pan S, Jensen AA, Wood NA, Henrichfreise B, Brötz-Oesterhelt H, Fisher DJ, Sass P, Ouellette SP. Molecular characterization of the ClpC AAA+ ATPase in the biology of Chlamydia trachomatis. mBio (2023).

Puls JS, Brajtenbach D, Schneider T, Kubitscheck U, Grein F. Inhibition of peptidoglycan synthesis is sufficient for total arrest of staphylococcal cell division. Sci Adv. doi: 10.1126/sciadv.ade9023 (2023).
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Aryal N, Chen J, Bhattarai K, Hennrich O, Handayani I, Kramer M, Straetener J, Wommer T, Berscheid A, Peter S, Reiling N, Brötz-Oesterhelt H, Geibel C, Lämmerhofer M, Mast Y, Gross H. High plasticity of the amicetin biosynthetic pathway in Streptomyces sp. SHP 22-7 led to the discovery of streptcytosine P and cytosaminomycins F and G and facilitated the production of 12F-plicacetin. J Nat Prod.  (2022).

Bär D, Konetschny B, Kulik A, Xu H, Paccagnella D, Beller P, Ziemert N, Dickschat JS, Gust B. Origin of the 3-methylglutaryl moiety in caprazamycin biosynthesis. Microb Cell Fact. (2022).

Esser A, Mayer G. Characterization of the glmS ribozymes from Listeria monocytogenes and Clostridium difficile. Chem. Eur. J., (2022).

Gavriilidou A, Kautsar SA, Zaburannyi N, Krug D, Müller R, Medema MH, Ziemert N. Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes. Nat Microbiol. (2022).

Geraci I, Autour A, Pietruschka G, Shiian A, Borisova M, Mayer C, Ryckelynck M, Mayer G. Fluorogenic RNA-based biosensor to sense the glycolytic flux in mammalian cells. ACS Chem. Biol. (2022).

Gottstein J, Zaschke-Kriesche J, Unsleber S, Voitsekhovskaia I, Kulik A, Behrmann LV, Overbeck N, Stühler K, Stegmann E, Smits SHJ. New insights into the resistance mechanism for the BceAB-type transporter SaNsrFP. Sci Rep. (2022).

Gratani FL, Englert T, Nashier P, Sass P, Mann P, Czech L, Neumann N, Doello S, Blobelt R, Alberti S, Forchhammer K, Bange G, Höfer K, Macek B. E. coli toxin YjjJ (HipH) is a Ser/Thr protein kinase that impacts cell division, carbon metabolism and ribosome assembly. mSystems (2022).

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Huang L, Matsuo M, Calderón C, Fan SH, Ammanath AV, Fu X, Li N, Luqman A, Ullrich M, Herrmann F, Maier M, Cheng A, Zhang F, Oesterhelt F, Lämmerhofer M, Götz F. Molecular basis of rhodomyrtone resistance in Staphylococcus aureus. mBio. (2022).

Kengmo Tchoupa A, Eijkelkamp BA, Peschel A. Bacterial adaptation strategies to host-derived fatty acids. Trends Microbiol. doi: 10.1016/j.tim.2021.06.002. (2022).

Kim L, Lee BG, Kim M, Kim MK, Kwon DH, Kim H, Brötz-Oesterhelt H, Roh SH, Song HK. Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis. EMBO J. doi: 10.15252/embj.2021109755 (2022).

Kohga H, Mori T, Tanaka Y, Yoshikaie K, Taniguchi K, Fujimoto K, Fritz L, Schneider T, Tsukazaki T. Crystal structure of the lipid flippase MurJ in a "squeezed" form distinct from its inward- and outward-facing forms. Structure. (2022).

Krakau S, Straub D, Gourlé H, Gabernet G, Nahnsen S. nf-core/mag: a best-practice pipeline for metagenome hybrid assembly and binning. NAR Genomics and Bioinformatics. (2022).

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Kuhn Cuellar L, Friedrich A, Gabernet G, de la Garza L, Fillinger S, Seyboldt A, Koch T, Zur Oven-Krockhaus S, Wanke F, Richter S, Thaiss WM, Horger M, Malek N, Harter K, Bitzer M, Nahnsen S. A data management infrastructure for the integration of imaging and omics data in life sciences. BMC Bioinformatics. (2022).

Lammers A, Lalk M, Garbeva P. Air ambulance: antimicrobial power of bacterial volatiles. Antibiotics. (2022).

Malik IT, Hegemann JD, Brötz-Oesterhelt H. Generation of lasso peptide-based ClpP binders. Int J Mol Sci. (2022). 

Mendes  SS, Marques J, Mesterházy E, Straetener J, Arts M, Pissarro T, Reginold J, Berscheid A, Bornikoel J, Kluj RM, Mayer C, Oesterhelt F, Friães S, Royo B, Schneider T, Brötz-Oesterhelt H, Romão CC, Saraiva LM. Synergetic antimicrobial activity and mechanism of clotrimazole-linked CO-releasing molecules. ACS Bio & Med Chem Au. (2022).

Meringdal JW, Kilian A, Li WC, Heinemann MJB, Rausch M, Schneider T, Menche D. Modular synthesis of halogenated xanthones by a divergent coupling strategy. J Org Chem. (2022).

Morris MA, Vallmitjana A, Grein F, Schneider T, Arts M, Jones CR, Nguyen BT, Hashemian MH, Malek M, Gratton E, Nowick JS. Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus subtilis. Chem Sci. (2022).

Mungan MD, Harbig TA, Perez NH, Edenhart S, Stegmann E, Nieselt K, Ziemert N. Secondary Metabolite Transcriptomic Pipeline (SeMa-Trap), an expression-based exploration tool for increased secondary metabolite production in bacteria. Nucleic Acids Res. (2022). 

Peter M, Ruland J, Depping P, Schneberger N, Severi E, Gatterdam K, Tindall S, Durand A, Heinz V, Siebrasse JP, Koenig PA, Geyer M, Ziegler C, Kubitscheck U, Thomas GH and Hagelueken G. Structural and mechanistic analysis of tripartite ATP-independent periplasmic (TRAP) transporters. Nat Commun. 13:4471, (2022).  

Reher R, Aron AT, Fajtová P, Stincone P, Wagner B, Pérez-Lorente AI, Liu C, Shalom IYB, Bittremieux W, Wang M, Jeong K, Matos-Hernandez ML, Alexander KL, Caro-Diaz EJ, Naman CB, Scanlan JHW, Hochban PMM, Diederich WE, Molina-Santiago C, Romero D, Selim KA, Sass P, Brötz-Oesterhelt H, Hughes CC, Dorrestein PC, O'Donoghue AJ, Gerwick WH, Petras D. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nat Commun. 13(1):4619. (2022). 

Reinhardt L, Thomy D, Lakemeyer M, Westerman LM, Ortega JP, Sieber, SA, Sass P,  Brötz-Oesterhelt H. Antibiotic acyldepsipeptides stimulate the Streptomyces Clp-ATPase/ClpP complex for accelerated proteolysis. mBio (2022). 

Šarić E, Quinn GA, Nalpas N, Paradžik T, Kazazić S, Filić Ž, Šemanjski M, Herron P, Hunter I, Maček B, Vujaklija D. Phosphoproteome dynamics of Streptomyces rimosus during submerged growth and antibiotic production. mSystems. doi: 10.1128/msystems.00199-22. (2022). 

Schultz D, Cuypers F, Skorka SB, Rockstroh J, Gesell Salazar M, Krieger J, Albrecht D, Völker U, Hammerschmidt S, Lalk M, Siemens N, Methling K. Bioactive lipid screening during respiratory tract infections with bacterial and viral pathogens in mice. Metabolomics. (2022).

Schulz S, Schall C, Stehle T, Breitmeyer C, Krysenko S, Mitulski A, Wohlleben W. Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis. Front Bioeng Biotechnol. (2022).

Slavetinsky CJ, Hauser JN, Gekeler C, Slavetinsky J, Geyer A, Kraus A, Heilingbrunner D, Wagner S, Tesar M, Krismer B, Kuhn S, Ernst CM, Peschel A. Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF. Elife. (2022).

Stängle D, Silkenath B, Gehle P, Esser A, Mayer G, Wittmann V. Carba-sugar analogs of glucosamine-6-phosphate: New activators for the glmS riboswitch. Chemistry. doi.10.1002/chem.202202378 (2022).

Xu H, Wochele A, Luo M, Schnakenburg G, Sun Y, Brötz-Oesterhelt H, Dickschat JS. Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites. Beilstein J Org Chem. doi: 10.3762/bjoc.18.120.  (2022).

Yin Z, Bär D, Gust B, Dickschat JS. The substrate scope of dehydratases in antibiotic biosynthesis and their application in kinetic resolutions. Org Biomol Chem. (2022).

Yin Z, Liebhart E, Stegmann E, Brötz-Oesterhelt H, Dickschat JS. An isotopic probe to follow the stereochemical course of dehydratase reactions in polyketide and fatty acid biosynthesis. Org Chem Front. (2022).

Zhang L, Esquembre LA, Xia SN, Oesterhelt F, Hughes CC, Brötz-Oesterhelt H, Teufel R. Antibacterial synnepyrroles from human-associated Nocardiopsis sp. show protonophore activity and disrupt the bacterial cytoplasmic membrane. ACS Chem Biol. doi: 10.1021/acschembio.2c00460 (2022). 



Beck C, Gren T, Ortiz-López FJ, Jørgensen TS, Carretero-Molina D, Martín Serrano J, Tormo JR, Oves-Costales D, Kontou EE, Mohite OS, Mingyar E, Stegmann E, Genilloud O, Weber T. Activation and identification of a griseusin cluster in Streptomyces sp. CA-256286 by employing transcriptional regulators and multi-omics methods. Molecules. (2021).

Brötz-Oesterhelt H and Vorbach A. Reprogramming of the caseinolytic protease by ADEP antibiotics: Molecular mechanism, cellular consequences, therapeutic potential.  Frontiers in Molecular Biosciences. (2021).

Chevrette MG, Gavriilidou A, Mantri S, Selem-Mojica N, Ziemert N, Barona-Gomez F. The confluence of big data and evolutionary genome mining for the discovery of natural products. Nat Prod Rep. (2021).

Dietrich A, Steffens U, Sass P, Bierbaum G. The hypersusceptible antibiotic screening strain Staphylococcus aureus SG511-Berlin harbors multiple mutations in regulatory genes. Int J Med Microbiol. (2021).

Drayton M, Deisinger JP, Ludwig KC, Raheem N, Müller A, Schneider T, Straus SK. Host defense peptides: Dual antimicrobial and immunomodulatory action. Int J Mol Sci. (2021).

Fan SH, Liberini E, Götz F. Staphylococcus aureus genomes harbor only MpsAB-like bicarbonate transporter but not carbonic anhydrase as dissolved inorganic carbon supply system. Microbiology Spectrum. (2021).

Fišarová L, Botka T, Du X, Mašlaňová I, Bárdy P, Pantůček R, Benešík M, Roudnický P, Winstel V, Larsen J, Rosenstein R, Peschel A, Doškař J. Staphylococcus epidermidis phages transduce antimicrobial resistance plasmids and mobilize chromosomal islands. mSphere.  (2021).

Greinacher A, Selleng K, Palankar R, Wesche J, Handtke S, Wolff M, Aurich K, Lalk M, Methling K, Volker U, Hentschker C, Michalik S, Steil L, Reder A, Schönborn L, Beer M, Franzke K, Büttner A, Fehse B, Stavrou EX, Rangaswamy C, Mailer RK, Englert H, Frye M, Thiele T, Kochanek S, Krutzke L, Siegerist F, Endlich N, Warkentin TE, Renné T. Insights in ChAdOx1 nCov-19 Vaccine-induced immune thrombotic thrombocytopenia (VITT). Blood. (2021).
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Heilbronner S, Krismer B, Brötz-Oesterhelt H, Peschel A. The microbiome-shaping roles of bacteriocins. Nat Rev Microbiol. (2021).
Illigmann A, Thoma Y, Pan S, Reinhardt L, Brötz-Oesterhelt H. Contribution of the Clp protease to bacterial survival and mitochondrial homoeostasis. Microb Physiol. (2021).
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Müller M, Calvert C, Hottmann I, Kluj RM, Teufel T, Balbuchta K, Engelbrecht A, Selim KA, Xu Q, Borisova M, Titz A, Mayer C. The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosamini-dases. J Biol Chem. (2021).
Nalpas N, Hoyles L, Anselm V, Ganief T, Martinez-Gili L, Grau C, Droste-Borel I, Davidovic L, Altafaj X, Dumas M-EMacek B. An integrated workflow for enhanced taxonomic and functional coverage of the mouse faecal metaproteome.
AEG, Muschiol S, Nannapaneni P, Eriksson A, Schneider T, Normark S, Henriques-Normark B, Almqvist F, Mellroth P. THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates. PNAS. (2021).
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Spindler S, Wingen LM, Schönenbroicher M, Seul M, Adamek M, Essig S, Kurz M, Ziemert N, Menche D. Modular fragment synthesis and bioinformatic analysis propose a revised vancoresmycin stereoconfiguration. (Honorary graphical illustration of the cover art) Org Lett. (2021).
Torres Salazar BO, Heilbronner S, Peschel A, Krismer B. Secondary metabolites governing microbiome interaction of staphylococcal pathogens and commensals. Microb Physiol. (2021).
Walter A, Friz S, Mayer C. Chitin, chitin oligosaccharide, and chitin disaccharide metabolism of Escherichia coli Revisited: Reassignment of the roles of ChiA, ChbR, ChbF, and ChbG. Microb Physiol. (2021).
Wewer W, Peisker H, Gutbrod K, Al-Bahra M, Menche D, Ngongeh Amambo G, Fombad FF, Jelil Njouendou A, Pfarr K, Wanji S, Hoerauf A, Dörmann P. Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon. Parasites Vectors. (2021).
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Babczyk A, Wingen LM, Menche D. Optimized and scalable synthesis of carba-α-D-glucosamine. Eur. J. Org. Chem. (2020).

Chen J, Frediansyah A, Männle D, Straetener J, Brötz-Oesterhelt H, Ziemert N, Kaysser L, Gross H. New nocobactin derivatives with antimuscarinic activity, terpenibactins A-C, revealed by genome mining of Nocardia terpenica IFM 0406. Chembiochem. (2020).

Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nature Biotechnology. (2020).

Grein F, Müller A, Scherer KM, Liu X, Ludwig KC, Klöckner A, Strach M, Sahl HG, Kubitscheck U, Schneider T. Ca2+- Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids. Nature Communication. (2020).

Krauss S, Zipperer A, Wirtz S, Saur J, Konnerth MC, Heilbronner S, Torres Salazar BO, Grond S, Krismer B, Peschel A. Secretion of and self-resistance to the novel fibupeptide antimicrobial lugdunin by distinct ABC transporters in Staphylococcus lugdunensis. Antimicrob Agents Chemother. (2020). 

Kumuthini J, Chimenti M, Nahnsen S, Peltzer A, Meraba R, McFadyen R, Wells G, Taylor D, Maienschein-Cline M, Li JL, Thimmapuram J, Murthy-Karuturi R, Zass L. Ten simple rules for providing effective bioinformatics research support. PLoS Comput Biol. (2020).

Malik IT, Pereira R, Vielberg MT, Mayer C, Straetener J, Thomy D, Famulla K, Castro H, Sass P, Groll M, Brötz-Oesterhelt H. Functional characterisation of ClpP mutations conferring resistance to acyldepsipeptide antibiotics in Firmicutes. Chembiochem. (2020).

Matos de Opitz CL, Sass P. Tackling antimicrobial resistance by exploring new mechanisms of antibiotic action. Fut Microbiol. (2020).

Nega M, Tribelli PM, Hipp K, Stahl M, Götz F. New insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus. Commun Biol. (2020).

Nguyen MT, Matsuo M, Niemann S, Herrmann M, Götz F. Lipoproteins in Gram-positive bacteria: abundance, function, fitness. Front Microbiol 11:582582. (2020).

Raue S, Fan S-H, Rosenstein R, Zabel S, Luqman A, Nieselt K, Götz F. The genome of Staphylococcus epidermidis O47. Front Microbiol. (2020).

Rivière S, Vielmuth C, Ennenbach C, Abdelrahman a, Lemke C, Gütschow M, Müller CE, Menche D. Design, synthesis and biological evaluation of highly potent simplified archazolids. Chem Med Chem. (2020).

Sassine J, Sousa J, Lalk M, Daniel RA, Vollmer W. Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis. Sci Rep. (2020). 

Scheeff S, Rivière S, Ruiz J, Abdelrahman A, Schulz-Fincke AC, Köse M, Tiburcy F, Wieczorek H, Gütschow M, Müller CE, Menche D. Synthesis of novel potent archazolids: Pharmacology of an emerging class of anticancer drugs. J Med Chem. (2020).

Silber N, Matos de Opitz CL, Mayer C, Sass P. Cell division protein FtsZ: from structure and mechanism to antibiotic target. Fut Microbiol. (2020).

Silber N, Pan S, Schäkermann S, Mayer C, Brötz-Oesterhelt H, Sass P. Cell division protein FtsZ is unfolded for N-terminal degradation by antibiotic-activated ClpP. mBio. (2020).

Walter A, Unsleber S, Rismondo J, Jorge AM, Peschel A, Gründling A, Mayer C. Phosphoglycerol-type wall and lipoteichoic acids are enantiomeric polymers differentiated by the stereospecific glycerophosphodiesterase GlpQ. J Biol Chem. (2020).

Wingen LM, Rausch M, Schneider T, Menche D. Synthesis of tetramic acid fragments derived from vancoresmycin showing inhibitory effects towards S. aureus. Chem Med Chem. (2020).

Wingen LM, Rausch M, Schneider T, Menche D. Modular total synthesis of farnesyl analogues of cell wall precursors lipid I and II containing the Staphylococcus aureus pentaglycine bridge modification. J Org Chem. (2020).

Wollnitzke P, Essig S, Gölz JP, von Schwarzenberg K, Menche D. Total synthesis of ajudazol A by a modular oxazole diversification strategy. Org Lett. (2020).

Wosniok PR, Knopf C, Dreisigacker S, Orozco-Rodriguez JM, Hinkelmann B, Müller PP, Brönstrup M, Menche D. SAR studies of the leupyrrins: Design and total synthesis of highly potent simplified leupylogs. (Honorary graphical illustration of the cover). Chemistry. (2020).



Dörr T, Moynihan PJ, Mayer C. Bacterial cell wall structure and dynamics. Frontiers in Microbiology. (2019).

Macek B, Forchhammer K, Hardouin J, Weber-Ban E, Grangeasse C, Mijakovic I. Protein post-translational modifications in bacteria. Nature Reviews Microbiology. (2019).

Mayer C, Sass P, Brötz-Oesterhelt H. Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics. International Journal of Medical Microbiology. (2019).

Mayer C. Peptidoglycan recycling, a promising target for antibiotic adjuvants in antipseudomonal therapy. The Journal of Infectious Diseases. (2019).

Nöldeke ER, Stehle TUnraveling the mechanism of peptidoglycan amidation by the bifunctional enzyme complex GatD/MurT: A comparative structural approach. Int J Med Microbiol.  309(6):151334. (2019). 

Pan S, Malik IT, Thomy D, Henrichfreise B, Sass P. The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci. Scientific Reports. (2019).

Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P, Brötz-Oesterhelt H. The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor. Applied and Environmental Microbiology, AEM-01292. (2019).