Publications
2021
Brötz-Oesterhelt H and Vorbach A. Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential. Frontiers in Molecular Biosciences https://doi.org/10.3389/fmolb.2021.690902 (2021).
Guo Y, Pfahler N, Voelpel S, Stehle T. Cell wall glycosylation in Staphylococcus aureus: Targeting the Tar glycosyltransferases. Curr Opin Struct Biol https://doi.org/10.1016/j.sbi.2021.01.003 (2021).
Handayani I, Saad H, Ratnakomala S, Lisdiyanti P, Kusharyoto W, Krause J, Kulik A, Wohlleben W, Aziz S, Gross H, Gavriilidou A, Ziemert N, Mast Y. Mining Indonesian Microbial Biodiversity for Novel Natural Compounds by a Combined Genome Mining and Molecular Networking Approach. Marine Drugs. https://doi.org/10.3390/md19060316 (2021).
Heilbronner S, Krismer B, Brötz-Oesterhelt H, Peschel A. The microbiome-shaping roles of bacteriocins. Nat Rev Microbiol https://doi.org/10.1038/s41579-021-00569-w (2021).
Izoré T, Candace Ho YT, Kaczmarski JA, Gavriilidou A, Chow KH, Steer DL, Goode RJA, Schittenhelm RB, Tailhades J, Tosin M, Challis GL, Krenske EH, Ziemert N, Jackson CJ, Cryle MJ. Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity. Nature Communications. https://doi.org/10.1038/s41467-021-22623-0 (2021).
Silber N, Mayer C, Matos de Opitz CL, Sass P. Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool. Commun Biol https://doi.org/10.1038/s42003-021-01789-9 (2021).
Spindler S, Wingen LM, Schönenbroicher M, Seul M, Adamek M, Essig S, Kurz M, Ziemert N, Menche D. Modular Fragment Synthesis and Bioinformatic Analysis Propose a Revised Vancoresmycin Stereoconfiguration. (Honorary graphical illustration of the cover art) Org. Lett. https://doi.org/10.1021/acs.orglett.0c03957 (2021).
Wirtz DA, Ludwig KC, Arts M, Marx CE, Krannich S, Barac P, Kehraus S, Josten M, Henrichfreise B, Müller A, König GM, Peoples AJ, Nitti A, Spoering AL, Ling LL, Lewis K, Crüsemann M, Schneider T. Biosynthesis and mechanism of action of the cell wall targeting antibiotic hypeptin. Angewandte Chemie. https://doi.org/10.1002/ange.202102224 (2021).
2020
Babczyk A, Wingen LM, Menche D. Optimized and Scalable Synthesis of Carba-α-D-Glucosamine. Eur. J. Org. Chem. https://doi.org/10.1002/ejoc.202001203 (2020).
Chen J, Frediansyah A, Männle D, Straetener J, Brötz-Oesterhelt H, Ziemert N, Kaysser L, Gross H. New nocobactin derivatives with antimuscarinic activity, terpenibactins A-C, revealed by genome mining of Nocardia terpenica IFM 0406. Chembiochem. https://doi.org/10.1002/cbic.202000062 (2020).
Ewels PA, Peltzer A, Fillinger S, Patel H, Alneberg J, Wilm A, Garcia MU, Di Tommaso P, Nahnsen S. The nf-core framework for community-curated bioinformatics pipelines. Nature Biotechnology. https://doi.org/10.1038/s41587-020-0439-x (2020).
Grein F, Müller A, Scherer KM, Liu X, Ludwig KC, Klöckner A, Strach M, Sahl HG, Kubitscheck U, Schneider T. Ca2+- Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids. Nature Communication. https://doi.org/10.1038/s41467-020-15257-1 (2020).
Krauss S, Zipperer A, Wirtz S, Saur J, Konnerth MC, Heilbronner S, Torres Salazar BO, Grond S, Krismer B, Peschel A. Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis. Antimicrob Agents Chemother.https://aac.asm.org/content/65/1/e01734-20 (2020).
Kumuthini J, Chimenti M, Nahnsen S, Peltzer A, Meraba R, McFadyen R, Wells G, Taylor D, Maienschein-Cline M, Li JL, Thimmapuram J, Murthy-Karuturi R, Zass L. Ten simple rules for providing effective bioinformatics research support. PLoS Comput Biol. https://doi.org/10.1371/journal.pcbi.1007531 (2020).
Malik IT, Pereira R, Vielberg MT, Mayer C, Straetener J, Thomy D, Famulla K, Castro H, Sass P, Groll M, Brötz-Oesterhelt H. Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes. Chembiochem. https://doi.org/10.1002/cbic.201900787 (2020).
Matos de Opitz CL, Sass P. Tackling antimicrobial resistance by exploring new mechanisms of antibiotic action. Fut Microbiol. https://doi.org/10.2217/fmb-2020-0048 (2020).
Nega M, Tribelli PM, Hipp K, Stahl M, Götz F. New insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus. Commun Biol. https://doi.org/10.1038/s42003-020-01405-2 (2020).
Raue S, Fan S-H, Rosenstein R, Zabel S, Luqman A, Nieselt K, Götz F. The Genome of Staphylococcus epidermidis O47. Front Microbiol. https://doi.org/10.3389/fmicb.2020.02061 (2020).
Rivière S, Vielmuth C, Ennenbach C, Abdelrahman a, Lemke C, Gütschow M, Müller CE, Menche D. Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids. Chem Med Chem. https://doi.org/10.1002/cmdc.202000154 (2020).
Scheeff S, Rivière S, Ruiz J, Abdelrahman A, Schulz-Fincke AC, Köse M, Tiburcy F, Wieczorek H, Gütschow M, Müller CE, Menche D. Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs. J Med Chem. https://doi.org/10.1021/acs.jmedchem.9b01887 (2020).
Silber N, Matos de Opitz CL, Mayer C, Sass P. Cell division protein FtsZ: from structure and mechanism to antibiotic target. Fut Microbiol. https://doi.org/10.2217/fmb-2019-0348 (2020).
Silber N, Pan S, Schäkermann S, Mayer C, Brötz-Oesterhelt H, Sass P. Cell division protein FtsZ is unfolded for N-terminal degradation by antibiotic-activated ClpP. mBio. https://doi.org/10.1128/mBio.01006-20 (2020).
Wingen LM, Rausch M, Schneider T, Menche D. Synthesis of Tetramic Acid Fragments Derived from Vancoresmycin Showing Inhibitory Effects towards S. aureus. Chem Med Chem. https://doi.org/10.1002/cmdc.202000241 (2020).
Wingen LM, Rausch M, Schneider T, Menche D. Modular Total Synthesis of Farnesyl Analogues of Cell Wall Precursors Lipid I and II Containing the Staphylococcus aureus Pentaglycine Bridge Modification. J Org Chem. https://doi.org/10.1021/acs.joc.0c01004 (2020).
Wollnitzke P, Essig S, Gölz JP, von Schwarzenberg K, Menche D. Total Synthesis of Ajudazol A by a Modular Oxazole Diversification Strategy. Org Lett. https://doi.org/10.1021/acs.orglett.0c02188 (2020).
Wosniok PR, Knopf C, Dreisigacker S, Orozco-Rodriguez JM, Hinkelmann B, Müller PP, Brönstrup M, Menche D. SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs. (Honorary graphical illustration of the cover). Chemistry. https://doi.org/10.1002/chem.202002622 (2020).
2019
Dörr T, Moynihan PJ, Mayer C. Bacterial Cell Wall Structure and Dynamics. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2019.02051 (2019).
Macek B, Forchhammer K, Hardouin J, Weber-Ban E, Grangeasse C, Mijakovic I. Protein post-translational modifications in bacteria. Nature Reviews Microbiology. https://doi.org/10.1038/s41579-019-0243-0 (2019).
Mayer C, Sass P, Brötz-Oesterhelt H. Consequences of dosing and timing on the antibacterial effects of ADEP antibiotics. International Journal of Medical Microbiology. https://doi.org/10.1016/j.ijmm.2019.151329 (2019).
Mayer C. Peptidoglycan Recycling, a Promising Target for Antibiotic Adjuvants in Antipseudomonal Therapy. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiz378 (2019).
Nguyen MT, Saising J, Tribelli PM, Nega M, Diene SM, François P, Schrenzel J, Spröer C, Bunk B, Ebner P, Hertlein T, Kumari N, Härtner T, Wistuba D, Voravuthikunchai SP, Mäder U, Ohlsen K, Götz F. Inactivation of farR causes high rhodomyrtone resistance and increased pathogenicity in Staphylococcus aureus. Frontiers in Microbiology. https://dois.org/10.3389/fmicb.2019.01157 (2019).
Pan S, Malik IT, Thomy D, Henrichfreise B, Sass P. The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci. Scientific Reports. https://doi.org/10.1038/s41598-019-50505-5 (2019).
Thomy D, Culp E, Adamek M, Cheng EY, Ziemert N, Wright GD, Sass P, Brötz-Oesterhelt H. The ADEP biosynthetic gene cluster in Streptomyces hawaiiensis NRRL 15010 reveals an accessory clpP gene as a novel antibiotic resistance factor. Applied and Environmental Microbiology, AEM-01292. https://doi.org/10.1128/AEM.01292-19 (2019). [For a free e-print, write to dhana-manon.thomyuni-tuebingen.de]