Research Projects

Principal investigators and projects

Project Area A:

Antibiotic activities in target cells

A01
Mechanism of prokaryotic specificity of ADEP antibiotics
A02
Disturbing bacterial morphogenesis by antibiotic action
A03
Impact of carba-glucosamine on bacterial cell metabolism
A04
Mode of action of rhodomyrtone (Rom) and synthesized derivatives and studying the resistance mechanism mediated by FarE/FarR
A06
Cellular responses to the antibiotic fosfomycin
A07
Mechanisms of β-lactam induced persistence in chlamydiae
A08
Mode of action of cell wall biosynthesis inhibitors in Wolbachia spp.
A09
Recognition mechanisms of guanidine-containing lipopeptide antibiotics for cell wall precursor targets
A10
From primary target inhibition to collapse of the cell envelope biosynthetic network
A11
Impact of antibiotics on the spatio-temporal organization of the cell wall biosynthesis machinery

Project Area B:

Antibiotic biosynthesis in producer cells

B01
Spatial and temporal cellular assembly of the glycopeptide biosynthetic complex
B02
Functional dissection of transport processes during glycopeptide antibiotic production
B03
Cellular responses to heterologously expressed antibiotic gene clusters
B04
Horizontal transfer, evolution and cellular integration of Staphylococcus antibiosis islands
B05
Cellular adaptation mechanisms to horizontal gene transfer of antibiotic gene clusters in the model system Amycolatopsis
B06
Phosphopantetheinyl transferases in antibiotic biosynthesis
B07
Effects of double bond shifts in polyketide biosynthesis
B08
Structures of cellular machineries relevant for antibiotic synthesis and action

Project Area Z:

Central and service projects

Z01
Chemical analysis, isolation and synthesis of antibiotics
Z02
Advanced fluorescence microscopy
Z03
Omics analysis and bioinformatics
Z04
Central administration, coordination and future development of the TRR 261