New TRR-publication! The Substrate Scope of Dehydratases in Antibiotic Biosynthesis and their Application in Kinetic Resolutions
Congratulations to Zhiyong Yin, Daniel Baer, Bertolt Gust and Jeroen Dickschat on their recent publication!
Abstract
Nine dehydratases involved in the biosynthesis of secondary metabolites in addition to FabZ from fatty acid biosynthesis were investigated for their substrate scope using a panel of N-acetylcysteamine (SNAC) thioesters. The best performing enzyme BorDH2 was applied in kinetic resolutions.
Full version of the paper: https://doi.org/10.1039/D2OB01879A