New paper! THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates
Considering the alarming emergence of resistance to most antibiotics and the need for new antibiotics, the finding here of a small-molecule class, THCz, that displayed bactericidal activity against gram-positive and selected gram-negative bacteria, is of the greatest importance. Authors found that THCz target the cell envelope synthesis and can easily be synthesized and modified, and resistance did not readily develop in vitro. Thus, THCz are promising scaffolds for development of bacterial cell wall inhibitors.
Congratulations to, Anna Müller, Tanja Schneider, Fabian Grein, and all coauthors!